Research recommendations coming out of this guidance What is the clinical and cost effectiveness of using different thresholds of LDL‑C concentration in primary care case finding? What are the long-term effects of statin therapy on sub-clinical atherosclerosis in children with FH who are treated with statin therapy? What is the clinical effectiveness and safety of differing doses of lipid-modifying therapy in children with FH? What are the appropriate indications, effectiveness and safety of LDL apheresis in people with heterozygous FH? What are the implications of FH for the safety of a mother during pregnancy and what are the risks of fetal malformations attributable to pharmacological therapies What is the utility of routine cardiovascular evaluation for asymptomatic people with FH?
What is the clinical and cost effectiveness of using different thresholds of LDL‑C concentration in primary care case finding?
What are the long-term effects of statin therapy on sub-clinical atherosclerosis in children with FH who are treated with statin therapy?
What is the clinical effectiveness and safety of differing doses of lipid-modifying therapy in children with FH?
What are the appropriate indications, effectiveness and safety of LDL apheresis in people with heterozygous FH?
What are the implications of FH for the safety of a mother during pregnancy and what are the risks of fetal malformations attributable to pharmacological therapies