Fezolinetant for treating vasomotor symptoms associated with the menopause [ID5071]

Suggested remit: To appraise the clinical and cost effectiveness of fezolinetant within its marketing authorisation for treating vasomotor symptoms associated with the menopause.

Status:

In progress

Technology type:

Medicine

Decision:

Selected

Reason for decision:

Anticipate the topic will be of importance to patients, carers, professionals, commissioners and the health of the public to ensure clinical benefit is realised, inequalities in use addressed, and help them make the best use of NHS resources

Process:

STA Standard

ID number:

5071

Project Team

Project lead

Leena Issa

Email enquiries

If you have any queries please email [email protected]

External Assessment Group:

Centre for Reviews and Dissemination and Centre for Health Economics, University of York

Stakeholders

Companies sponsors

Astellas Pharma (fezolinetant)

Others

Department of Health and Social Care

 

NHS England

Patient carer groups

Menopause and Cancer

Professional groups

British Menopause Society

 

Royal College of Physicians

 

Society for Endocrinology

 

UK Clinical Pharmacy Association

Associated public health groups

None

Comparator companies

HRT

 

Bayer (oestrogen) (confidentiality agreement signed, participating)

 

Gedeon Richter UK (oestrogen) (confidentiality agreement signed, participating)

 

ADVANZ Pharma (tibolone) (confidentiality agreement not signed, not participating)

 

Artisto Pharma (tibolone) (confidentiality agreement not signed, not participating)

 

Besins Healthcare (UK) (combined oestrogen/progesterone) (confidentiality agreement not signed, not participating)

 

Merus Labs Luxco II S.à R.L. (oestrogen) (confidentiality agreement not signed, not participating)

 

Mylan (oestrogen, combined oestrogen and progesterone) (confidentiality agreement not signed, not participating)

 

Novartis (oestrogen) (confidentiality agreement not signed, not participating)

 

Novo Nordisk (combined oestrogen and progesterone) (confidentiality agreement not signed, not participating)

 

Orion (oestrogen, combined oestrogen and progesterone) (confidentiality agreement not signed, not participating)

 

Organon Phama UK (tibolone) (confidentiality agreement not signed, not participating)

 

Pfizer (oestrogen, combined oestrogen and progesterone) (confidentiality agreement not signed, not participating)

 

Strides Pharma UK (tibolone) (confidentiality agreement not signed, not participating)

 

Theramex UK (oestrogen, progesterone, combined oestrogen and progesterone) (confidentiality agreement not signed, not participating)

 

Anti-depressants (SSRIs, SNRIs)

 

A. Menarini Farmaceutica Internazionale SRL (dapoxetine) (confidentiality agreement not signed, not participating)

 

Accord Healthcare (citalopram, escitalopram, fluoxetine, paroxetine, sertraline) (confidentiality agreement not signed, not participating)

 

Accord UK (citalopram, fluoxetine, paroxetine) (confidentiality agreement not signed, not participating)

 

ADVANZ Pharma (citalopram, fluoxetine, venlafaxine) (confidentiality agreement not signed, not participating)

 

Amarox (citalopram, duloxetine) (confidentiality agreement not signed, not participating)

 

Amdipharm (citalopram, venlafaxine) (confidentiality agreement not signed, not participating)

 

Aspire Pharma (duloxetine, venlafaxine) (confidentiality agreement not signed, not participating)

 

Aurobindo Pharma-Milpharm (citalopram, duloxetine, escitalopram, fluoxetine, paroxetine, sertraline, venlafaxine) (confidentiality agreement not signed, not participating)

 

Bristol Laboratories (venlafaxine) (confidentiality agreement not signed, not participating)

 

Brown & Burk UK (escitalopram, fluoxetine) (confidentiality agreement not signed, not participating)

 

Cipla EU (fluoxetine) (confidentiality agreement not signed, not participating)

 

Dexcel Pharma (venlafaxine) (confidentiality agreement not signed, not participating)

 

Dr Reddy’s Laboratory (duloxetine, fluoxetine, sertraline) (confidentiality agreement not signed, not participating)

 

Eli Lilly and Company (duloxetine) (confidentiality agreement not signed, not participating)

 

Endo Ventures (fluoxetine) (confidentiality agreement not signed, not participating)

 

Fannin UK (fluoxetine) (confidentiality agreement not signed, not participating)

 

Flamingo Pharma (fluoxetine, sertraline) (confidentiality agreement not signed, not participating)

 

GlaxoSmithKline (paroxetine) (confidentiality agreement not signed, not participating)

 

Glenmark Pharmaceuticals Europe (escitalopram) (confidentiality agreement not signed, not participating)

 

Krka UK (venlafaxine) (confidentiality agreement not signed, not participating)

 

Lundbeck (citalopram, escitalopram, vortioxetine) (confidentiality agreement not signed, not participating)

 

Lupin Healthcare (sertraline) (confidentiality agreement not signed, not participating)

 

Martindale Pharma, an Ethypharm Group Company (venlafaxine) (confidentiality agreement not signed, not participating)

 

Morningside Healthcare (paroxetine, venlafaxine) (confidentiality agreement not signed, not participating)

 

Mylan (dapoxetine, fluvoxamine, fluoxetine, sertraline) (confidentiality agreement not signed, not participating)

 

Neuraxpharm UK (duloxetine) (confidentiality agreement not signed, not participating)

 

Pinewoord Healthcare (fluoxetine) (confidentiality agreement not signed, not participating)

 

Ranbaxy Ltd (Sun Pharma) (sertraline, venlafaxine) (confidentiality agreement not signed, not participating)

 

Rivopharm UK (citalopram) (confidentiality agreement not signed, not participating)

 

Rosemont Pharmaceuticals (fluoxetine, venlafaxine) (confidentiality agreement not signed, not participating)

 

Sandoz (citalopram, paroxetine) (confidentiality agreement not signed, not participating)

 

Thame Laboratories (citalopram) (confidentiality agreement not signed, not participating)

 

Tillomed Laboratories (venlafaxine) (confidentiality agreement not signed, not participating)

 

Viatris (sertraline, venlafaxine) (confidentiality agreement not signed, not participating)

 

Zentiva (citalopram, sertraline) (confidentiality agreement not signed, not participating)

 

Zentiva (duloxetine) (confidentiality agreement not signed, not participating)

 

Clonidine

 

Sandoz (confidentiality agreement not signed, not participating)

 

Syri (confidentiality agreement not signed, not participating)

 

Anti-convulsants

 

ADVANZ Pharma (pregabalin) (confidentiality agreement not signed, not participating)

 

Amarox (gabapentin, pregabalin) (confidentiality agreement not signed, not participating)

 

Aristo Pharma (pregabalin) (confidentiality agreement not signed, not participating)

 

Aspire Pharma (pregabalin) (confidentiality agreement not signed, not participating)

 

Aurobindo Pharma - Milpharm (gabapentin, pregabalin) (confidentiality agreement not signed, not participating)

 

Brown & Burk UK (gabapentin, pregabalin) (confidentiality agreement not signed, not participating)

 

Colonis Pharma (gabapentin) (confidentiality agreement not signed, not participating)

 

Dr Reddy’s Laboratories (UK) (pregabalin) (confidentiality agreement not signed, not participating)

 

Glenmark Pharmaceuticals Europe (gabapentin) (confidentiality agreement not signed, not participating)

 

MSN Laboratories Europe (pregabalin) (confidentiality agreement not signed, not participating)

 

Mylan (pregabalin) (confidentiality agreement not signed, not participating)

 

Neuraxpharm UK (pregabalin) (confidentiality agreement not signed, not participating)

 

Northumbria Pharma (pregabalin) (confidentiality agreement not signed, not participating)

 

Ranbaxy (UK) Limited a Sun Pharmaceutical Company (pregabalin) (confidentiality agreement not signed, not participating)

 

Rivopharm UK (gabapentin) (confidentiality agreement not signed, not participating)

 

Rosemont Pharmaceuticals Limited (gabapentin, pregabalin) (confidentiality agreement not signed, not participating)

 

Sandoz Limited (pregabalin) (confidentiality agreement not signed, not participating)

 

Strides Pharma UK (gabapentin) (confidentiality agreement not signed, not participating)

 

Thame Laboratories (gabapentin) (confidentiality agreement not signed, not participating)

 

Tillomed Laboratories (gabapentin, pregabalin) (confidentiality agreement not signed, not participating)

 

Viatris (gabapentin, pregabalin) (confidentiality agreement not signed, not participating)

 

Wockhardt UK (pregabalin) (confidentiality agreement not signed, not participating)

 

Zentiva (pregabalin) (confidentiality agreement not signed, not participating)

General commentators

All Wales Therapeutics and Toxicology Centre

 

British National Formulary

 

Department of Health - Northern Ireland

 

Healthcare Improvement Scotland

 

Medicines and Healthcare products Regulatory Agency

 

NHS Wales Joint Commissioning Committee

 

Scottish Medicines Consortium

 

Welsh Government

Relevant research groups

Nottingham Clinical Trials Unit

Timeline

Key events during the development of the guidance:

For further information on our processes and methods, please see our CHTE processes and methods manual