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Narcolepsy with or without cataplexy in adults: pitolisant

  • Evidence summary
  • Reference number: ES8
  • Published:  14 March 2017

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  • Key points
  • Introduction and current guidance
  • Product overview
  • Evidence review
  • Estimated impact for the NHS
  • Information for the public about medicines
  • Relevance to other NICE programmes
  • References
  • Evidence tables
  • Results tables
  • Excluded studies
  • Terms used in this evidence summary
  • Search strategy
  • Development of this evidence summary

References

Baumann CR (2017) Wide implications of a trial on pitolisant for cataplexy. Lancet Neurology; published 24 January, DOI: http://dx.doi.org/10.1016/S1474-4422(16)30398-2

Billiard M, Bassetti C, Dauvilliers Y et al. (2006) EFNS guidelines on management of narcolepsy. European Journal of Neurology 13(10): 1035–48

Dauvilliers Y, Bassetti C, Lammers GJ et al. for the HARMONY I study group (2013) Pitolisant versus placebo or modafinil in patients with narcolepsy: a double-blind, randomised trial. Lancet Neurology 12(11): 1068–75

Sateia MJ (2014) International classification of sleep disorders-third edition: highlights and modifications. Chest 146(5): 1387–94

Szakacs Z, Dauvilliers Y, Mikhaylov V et al. for the HARMONY-CTP study group (2017) Safety and efficacy of pitolisant on cataplexy in patients with narcolepsy: a randomised, double-blind, placebo-controlled trial. Lancet Neurology; published 24 January, DOI: http://dx.doi.org/10.1016/S1474-4422(16)30333-7


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