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Chronic anal fissure: 0.2% topical glyceryl trinitrate ointment

  • Evidence summary
  • Reference number: ESUOM7
  • Published:  26 March 2013
  • Advice
  • Information for the public
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  • Key points from the evidence
  • Overview for healthcare professionals
  • Relevance to NICE guidance programmes
  • Intervention and alternatives
  • Evidence review: efficacy
  • Evidence review: safety
  • Evidence review: economic issues
  • Evidence strengths and limitations
  • Summary for patients
  • References
  • Development of this evidence summary
  • Appendix: Search strategy and evidence selection
  • About 'Evidence summaries: unlicensed or off-label medicines'

Relevance to NICE guidance programmes

The use of 0.2% glyceryl trinitrate for treating chronic anal fissure is not appropriate for referral for a NICE technology appraisal as it is not licensed for this indication. It is not currently planned into any other work programme.

Constipation in children and young people: diagnosis and management of idiopathic childhood constipation in primary and secondary care (NICE clinical guidelineĀ 99) identifies anal fissure as a possible finding in children with constipation but does not discuss its treatment specifically.


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