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  • Question on Consultation

    Has all of the relevant evidence been taken into account?

  • Question on Consultation

    Are the summaries of clinical and cost effectiveness reasonable interpretations of the evidence?

  • Question on Consultation

    Are the recommendations sound and a suitable basis for guidance to the NHS?

  • Question on Consultation

    Are there any aspects of the recommendations that need particular consideration to ensure we avoid unlawful discrimination against any group of people on the grounds of race, gender, disability, religion or belief, sexual orientation, age, gender reassignment, pregnancy and maternity?

1 Recommendations

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2 Information about dostarlimab

Marketing authorisation indication

2.1

Dostarlimab (Jemperli, GlaxoSmithKline) is indicated 'in combination with platinum-containing chemotherapy for the treatment of adult patients with primary advanced or recurrent endometrial cancer (EC) and who are candidates for systemic therapy'.

Dosage in the marketing authorisation

Price

2.3

The list price for dostarlimab is £5,887.33 per 500‑mg vial (excluding VAT; BNF online accessed July 2025).

2.4

The company has a commercial arrangement. This makes dostarlimab available to the NHS with a discount and it would have also applied to this indication if dostarlimab had been recommended. The size of the discount is commercial-in-confidence.

Carbon Reduction Plan

2.5

Information on the Carbon Reduction Plan for UK carbon emissions for GlaxoSmithKline will be included here when guidance is published.