Depression in adults: treatment and management

Consultation comments and responses A (PDF 6.25 MB)

Consultation comments and responses B (PDF 5.23 MB)

Consultation comments and responses C (PDF 1.47 MB)

Consultation comments and responses D (PDF 240 KB)

Equality impact assessment (PDF 158 KB)

Draft guidance consultation: (Nov 2021) 

Draft guideline (PDF 1.01 MB)

Evidence review A (PDF 5.42 MB)

Evidence review B (PDF 18.69 MB)

Evidence review C (PDF 4.24 MB)

Evidence review D (PDF 7.74 MB)

Evidence review E (PDF 2.85 MB)

Evidence review F (PDF 1.06 MB)

Evidence review G (PDF 956 KB)

Evidence review H (PDF 1.01 MB)

Evidence review I (PDF 1.51 MB)

Supporting documentation A1  (Excel 197 KB)

Supporting documentation A2 (Excel 304 KB)

Supporting documentation - Methods (PDF 568 KB)

Supporting documentation - Glossary and abbreviations (PDF 688 KB)

Supporting documentation - Economic evidence Included & excluded studies (Excel 52 KB)

Supporting documentation - Staff and contributors (PDF 215 KB)

Comments form (MSWord 40 KB)

Equality impact assessment 3 (PDF 146 KB)

Supporting documentation B1 (Excel 2.57 MB)

Supporting documentation B2 (PDF 4.71 MB)

Supporting documentation B3 (PDF 9.85 MB)

Supporting documentation B4 (Excel 26 KB)

Supporting documentation B5 (Unknown 5.29 MB)

Supporting documentation B6 (Unknown 25.77 MB)

Supporting documentation C (Excel 1.26 MB)

Supporting documentation D (Excel 5.54 MB)

Supporting documentation E (Excel 254 KB)

Supporting documentation F (Excel 105 KB)

Supporting documentation G (Excel 91 KB)

Supporting documentation H (Excel 50 KB)

Supporting documentation I (Excel 189 KB)

Supporting documentation - Less severe depression (PDF 161 KB)

Search strategies (PDF 1.37 MB)

Economic plan (PDF 135 KB)

Committee meeting

Minutes - Meeting 1 (PDF 270 KB)

Minutes - Meeting 2 (PDF 264 KB)

Minutes - Meeting 3 (PDF 177 KB)

Minutes - Meeting 4 (PDF 177 KB)

Minutes - Meeting 5 (PDF 90 KB)

Minutes - Meeting 6 (PDF 112 KB)

Minutes - Meeting 7 (PDF 123 KB)

Minutes - Meeting 8 (PDF 111 KB)

Minutes - Meeting 9 (PDF 108 KB)

Minutes meeting 10 (PDF 228 KB)

Minutes meeting 11 (PDF 211 KB)

Minutes 12 (PDF 231 KB)

Minutes - GC Meeting 13 (PDF 257 KB)

Minutes - meeting 14 (PDF 291 KB)

Minutes 15 (PDF 241 KB)

Minutes 16 (PDF 290 KB)

Minutes 17 (PDF 174 KB)

Minutes 18 (PDF 242 KB)

Minutes 19 (PDF 166 KB)

Minutes 20 (PDF 172 KB)

Minutes 21 (PDF 179 KB)

Minutes 21.5 (PDF 376 KB)

Minutes 22 (PDF 262 KB)

Minutes 23 (PDF 210 KB)

Minutes 24 (PDF 196 KB)

Minutes 25 (PDF 287 KB)

Minutes 26  (PDF 192 KB)

Minutes 26 (PDF 196 KB)

Minutes - 27 (Day1) (PDF 279 KB)

Minutes - 27 (Day2) (PDF 191 KB)

Draft guidance consultation: (May 2018) 

Short version of draft guideline (PDF 1.14 MB)

Full guideline updated (PDF 14.67 MB)

Consultation comments and responses 1st consultation period (PDF 11.27 MB)

Committee member list (PDF 517 KB)

Supporting documentation References (PDF 1.09 MB)

Comments form For second consultation (MSWord 63 KB)

Equality impact assessment 4 (PDF 324 KB)

Addendum appendicies A-G (PDF 1.82 MB)

Addendum appendicies O-R (PDF 4.74 MB)

Addendum appendix H - Search strategies for clinical evidence (PDF 361 KB)

Addendum appendix I - Search strategies for economic evidence (PDF 295 KB)

Addendum appendix J1.1 - Study characteristics, data extraction, outcomes & excluded studies for service delivery (Excel 157 KB)

Addendum appendix J1.2 - Study characteristics, data extraction, outcomes, excluded studies for settings for care (Excel 261 KB)

Addendum appendix J2 - Study characteristics, data extraction, outcomes, excluded studies for recognition, assessment & initial management (PDF 1.86 MB)

Addendum appendix J3.1 Study characteristics, data extraction, outcomes, excluded studies for NMA (Excel 2.14 MB)

Addendum appendix J3.2 - Risk of bias summary table by network (PDF 1.34 MB)

Addendum appendix J4 - Study characteristics, data extraction, outcomes, excluded studies for pairwise comparisons (Excel 101 KB)

Addendum appendix J5 - Study characteristics, data extraction, outcomes, excluded studies for further-line treatment (Excel 1.58 MB)

Addendum appendix J6 - Study characteristics, data extraction, outcomes, excluded studies for chronic depression (Excel 1.14 MB)

Addendum appendix J7 - Study characteristics, outcomes and excluded studies for complex depression (Excel 63 KB)

Addendum appendix J8 - Study characteristics, data extraction, outcomes, excluded studies for psychotic depression (Excel 84 KB)

Addendum appendix J9 - Study characteristics, data extraction, outcomes, excluded studies for relapse prevention (Excel 2.48 MB)

Addendum appendix J10 - Study characteristics, data extraction, outcomes, excluded studies for access to services (Excel 43 KB)

Addendum appendix J11 - Study characteristics, data extraction, outcomes & excluded studies for previous guidelines (PDF 1.66 MB)

Addendum appendix K - Clinical evidence flow charts (PDF 260 KB)

Addendum appendix L - Clinical evidence GRADE profiles (PDF 9.05 MB)

Addendum appendix M - Clinical evidence forest plots (PDF 8.02 MB)

Addendum appendix N1 - NMA treatments for new episode depression - methods & results (PDF 6.43 MB)

Addendum appendix N2 - NMA treatments for new episode depression - bias adjustment methods and results (PDF 1.47 MB)

Addendum appendix S - Economic evidence - list of excluded studies (Excel 22 KB)

Addendum appendix T - References to studies 2009 & 2004 (PDF 1.66 MB)

Addendum appendix N3 - NMA treatments for new episode depression - discontinuation with less severe depression (Excel 1.48 MB)

Addendum appendix N3 - NMA treatments for new episode depression - discontinuation SE less severe depression (Excel 199 KB)

Addendum appendix N3 - NMA treatments for new episode depression - remission in completers with less severe depression (Excel 796 KB)

Addendum appendix N3 - NMA treatments for new episode depression - remission randomised less severe depression (Excel 780 KB)

Addendum appendix N3 - NMA treatments for new episode depression - response to randomised less severe depression (Excel 949 KB)

Addendum appendix N3 - NMA treatments for new episode depression - response to completers less severe depression (Excel 5.15 MB)

Addendum appendix N3- NMA treatments for new episode depression - SMD less severe depression (Excel 701 KB)

Addendum appendix N3 - NMA treatments for new episode depression - discontinuation for more severe depression  (Excel 709 KB)

Addendum appendix N3 - NMA treatments for new episode depression - discontinuation to SE more severe depression (Excel 148 KB)

Addendum appendix N3 - NMA treatments for new episode depression - remission completers more severe depression (Excel 292 KB)

Addendum appendix N3 - NMA treatments for new episode depression - remission randomised more severe depression (Excel 293 KB)

Addendum appendix N3 - NMA treatments for new episode depression - response randomised more severe depression (Excel 418 KB)

Addendum appendix N3 - NMA treatments for new episode depression - reponse completers more severe depression (Excel 4.58 MB)

Addendum appendix N3 - NMA treatments for new episode depression - SMD more severe depression (Excel 390 KB)

Addendum appendix U1 - Text from CG90 full guideline that has been deleted (PDF 9.69 MB)

Addendum appendix U2.1 - Text from CG90 appendices that has been deleted (PDF 1.14 MB)

Addendum appendix U2.2- Text from CG90 Appendix 15 that has been deleted (PDF 860 KB)

Addendum appendix U2.3 - Text from CG90 Appendix 16a that has been deleted (PDF 737 KB)

Addendum appendix U2.4 - Text from CG90 Appendix 16b that has been deleted (PDF 6.56 MB)

Addendum appendix U2.5 - Text from CG90 Appendix 16c that has been deleted (PDF 5.31 MB)

Addendum appendix U2.6 - Text from CG90 Appendix 15d that has been deleted (PDF 1.78 MB)

Addendum appendix U2.7 - Text from CG90 Appendix 17a that has been deleted (PDF 1.39 MB)

Addendum appendix U2.8 - Text from CG90 Appendix 17b that has been deleted (PDF 3.02 MB)

Addendum appendix U2.9 - Text from CG90 Appendix 17c that has been deleted (PDF 6.32 MB)

Addendum appendix U2.10 - Text from CG90 Appendix 17d that has been deleted (PDF 1.06 MB)

Addendum appendix U2.11 - Text from CG90 Appendix 19a that has been deleted (PDF 1.6 MB)

Addendum appendix U2.12 - Text from CG90 Appendix 19b that has been deleted (PDF 5.65 MB)

Addendum appendix U2.13 - Text from CG90 Appendix 19c that has been deleted (PDF 8.49 MB)

Addendum appendix U2.14 - Text from CG90 Appendix 19d that has been deleted (PDF 1.75 MB)

Draft guidance consultation: (July 2017) 

Guideline appendix I (PDF 294 KB)

Guideline appendices A–G (PDF 1.79 MB)

Guideline appendices O–R (PDF 4.95 MB)

Guideline appendix H (PDF 334 KB)

Guideline appendix J 1.1 (Excel 153 KB)

Guideline appendix J 2 (PDF 2.23 MB)

Guideline appendix J 3.1 (Excel 2.05 MB)

Guideline appendix J 3 (PDF 1.34 MB)

Guideline appendix J 4 (Excel 71 KB)

Guideline appendix J 5 (Excel 1.26 MB)

Guideline appendix J 6 (Excel 1.08 MB)

Guideline appendix J 7 (Excel 63 KB)

Guideline appendix J 8 (Excel 84 KB)

Guideline appendix J 9 (Excel 3.22 MB)

Guideline appendix J 10 (PDF 1.97 MB)

Guideline appendix K (PDF 269 KB)

Guideline appendix L (PDF 8.64 MB)

Guideline appendix M (PDF 7.48 MB)

Guideline appendix N (PDF 1.33 MB)

Guideline appendix S (Excel 22 KB)

Guideline appendix T (Excel 136 KB)

Guideline appendix U (PDF 1.65 MB)

Guideline appendix V 1 (PDF 9.65 MB)

Guideline appendix V 2 (PDF 1.19 MB)

Guideline appendix V 3 (PDF 636 KB)

Guideline appendix W (Excel 381 KB)

Draft guideline Chapters 1–15 (PDF 22.49 MB)

Draft guideline Chapter 16 (PDF 1.27 MB)

Draft guideline Chapter 17 (PDF 10.53 MB)

Comments form (MSWord 62 KB)

Short version of draft guideline (PDF 1.06 MB)

Equality impact assessment Section 2 (PDF 161 KB)

Depression in adults (update): the scope

Depression in adults (update): final scope

Depression in adults (update): final scope

Depression in adults (update): final scope (PDF 184 KB)

Depression in adults (update): scope consultation comments and responses

Depression in adults (update): scope consultation comments and responses (PDF 734 KB)

Depression in adults (update): equality impact assessment

Depression in adults (update): equality impact assessment (PDF 166 KB)

Depression in adults (update): scope consultation information

Depression in adults (update): draft scope

Depression in adults (update): draft scope (PDF 187 KB)

Depression in adults (update): scoping workshop notes

Depression in adults (update): the guideline committee

Depression in adults (update): committee meeting minutes 1

Depression in adults (update): committee meeting minutes 1 (PDF 268 KB)

Depression in adults (update): committee membership