2 Information about ribociclib

Marketing authorisation indication

2.1

Ribociclib (Kisqali, Novartis) 'in combination with an aromatase inhibitor is indicated for the adjuvant treatment of patients with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative early breast cancer at high risk of recurrence. In pre- or perimenopausal women, or in men, the aromatase inhibitor should be combined with a luteinising hormone-releasing hormone (LHRH) agonist'.

Dosage in the marketing authorisation

Price

2.3

The list prices of ribociclib 200-mg tablets are:

  • £983.33 per 21-pack

  • £1,966.67 per 42-pack

  • £2,950.00 per 63-pack

    (excluding VAT; BNF online, accessed March 2025).

2.4

The company has a simple patient access scheme. This makes ribociclib available to the NHS with a discount. The size of the discount is commercial in confidence.

Carbon Reduction Plan

2.5

For information, Novartis did not disclose its Carbon Reduction Plan for UK carbon emissions.