Bortezomib monotherapy for relapsed multiple myeloma

Multiple myeloma - bortezomib: review decision - November 2012 information

Appendix A: GE decision paper

Appendix A: GE decision paper (PDF 74 KB)

Multiple myeloma - bortezomib: review proposal - March 2012 information

Appendix A: provisional matrix of stakeholders

Appendix A: provisional matrix of stakeholders (PDF 122 KB)

Appendix B: proposal paper presented to the Institute's Guidance Executive

Appendix B: proposal paper presented to the Institute's Guidance Executive (PDF 148 KB)

TA129 Multiple myeloma - bortezomib: review update - November 2011 information

TA129 Multiple myeloma - bortezomib: review update - January 2011 information

Bortezomib monotherapy for relapsed multiple myeloma (final appraisal determination)

Bortezomib monotherapy for relapsed multiple myeloma (final appraisal determination) information

Bortezomib monotherapy for relapsed multiple myeloma (final appraisal determination) (PDF 1.23 MB)

Response to comments received from consultees, commentators and the public on the post appeal Appraisal Consultation Document (May 2007 ACD)

Response to comments received from consultees, commentators and the public on the post appeal Appraisal Consultation Document (May 2007 ACD) (PDF 156 KB)

Consultee and commentator comments on the ACD

Manufacturer/sponsor submission from Janssen-Cilag

Manufacturer/sponsor submission from Janssen-Cilag (PDF 345 KB)

Cancer Network Pharmacists Forum and British Oncology Pharmacy (joint comments)

Cancer Network Pharmacists Forum and British Oncology Pharmacy (joint comments) (PDF 191 KB)

Myeloma UK

Myeloma UK (PDF 110 KB)

RCN

RCN (PDF 37 KB)

RCP

RCP (PDF 28 KB)

UK Myeloma Forum, the British Society for Haematology and the RC of Pathologists

UK Myeloma Forum, the British Society for Haematology and the RC of Pathologists (PDF 77 KB)

Commentator - DHSSPSNI

Commentator - DHSSPSNI (PDF 40 KB)

Commentator - Department of Health

Commentator - Department of Health (PDF 25 KB)

Professor Gareth Morgan

Professor Gareth Morgan (PDF 72 KB)

Supporting letter confirming the Velcade response scheme - Department of Health

Supporting letter confirming the Velcade response scheme - Department of Health (PDF 21 KB)

Supporting letter confirming the Velcade response scheme - Janssen Cilag

Supporting letter confirming the Velcade response scheme - Janssen Cilag (PDF 34 KB)

Supporting letter confirming the Velcade response scheme - WAG

Multiple myeloma - bortezomib: appraisal consultation

Multiple myeloma - bortezomib: appraisal consultation document information

Multiple myeloma - bortezomib: evaluation report

Additional analysis (post-appeal) from Ortho Biotech

Additional analysis (post-appeal) from Ortho Biotech (PDF 184 KB)

Department of Health response to responder scheme

Department of Health response to responder scheme (PDF 16 KB)

Department of Health summary of responder scheme

Department of Health summary of responder scheme (PDF 17 KB)

Welsh Assembly Government response to responder scheme

Welsh Assembly Government response to responder scheme (PDF 35 KB)

Janssen-Cilag - Issues for clarification

Janssen-Cilag - Issues for clarification (PDF 70 KB)

Further clarification

Further clarification (PDF 31 KB)

Table from Janssen-Cilag

Table from Janssen-Cilag (PDF 70 KB)

Comparative results from Jansen-Cilag

Comparative results from Jansen-Cilag (PDF 24 KB)

Incremental and Pairwise analysis (prepared by Technical Lead and Technical Adviser)

Incremental and Pairwise analysis (prepared by Technical Lead and Technical Adviser) (PDF 93 KB)

Additional expert statements detailing response to the request made by the Appeal Panel in terms of the three scenarios outlined in the Appeal Panel Decision

Cavenagh

Cavenagh (PDF 29 KB)

Jackson

Jackson (PDF 14 KB)

Jago

Jago (PDF 13 KB)

Morgan

Morgan (PDF 36 KB)

Low

Letter sent to consultees and commentators updating them on the status of the appraisal

Letter to Department of Health following Appeal Panel decision

Letter to consultees and commentators requesting views on unlicensed use

Letter to Janssen-Cilag (Ortho Biotech) following Appeal Panel decision requesting additional cost effectiveness evidence

Letter to Welsh Assembly Government following Appeal Panel decision

Multiple myeloma - bortezomib: Appeal panel decision

Appeal by Janssen-Cilag Ltd

Joint appeal by the Royal College of Pathologists and the British Society for Haematology

Covering letter for joint appeal by Myeloma UK, Cancerbackup and Leukaemia CARE

Joint appeal by Myeloma UK, Cancerbackup and Leukaemia CARE

Letter to John Redwood referenced in Myeloma UK joint submission

Appeal by UK Myeloma Forum

Final appraisal determination: Bortezomib monotherapy for relapsed multiple myeloma information

Final appraisal determination

Final appraisal determination (PDF 83 KB)

Response to consultee and commentator comments on the ACD

Response to consultee and commentator comments on the ACD (PDF 347 KB)

Response to patient carer organisations public and web comments on the ACD

Response to patient carer organisations public and web comments on the ACD (PDF 26 KB)

Response to professional organisation's public and web comments on the ACD

Response to professional organisation's public and web comments on the ACD (PDF 55 KB)

Consultee and commentator comments on the ACD

Department of Health

Department of Health (PDF 47 KB)

Department of Health, Social Services and Public Safety - Northern Ireland

Department of Health, Social Services and Public Safety - Northern Ireland (PDF 45 KB)

Leukaemia care

Leukaemia care (PDF 33 KB)

Leukemia Research, International Myeloma Foundation (UK) and Leukaemia Care

Leukemia Research, International Myeloma Foundation (UK) and Leukaemia Care (PDF 18 KB)

Leukemia Research, International Myeloma Foundation (UK), Leukaemia Care and Cancerbackup

Leukemia Research, International Myeloma Foundation (UK), Leukaemia Care and Cancerbackup (PDF 134 KB)

Royal College of Pathologists

Royal College of Pathologists (PDF 70 KB)

Royal College of Radiologists

Royal College of Radiologists (PDF 23 KB)

UK Myeloma Forum

UK Myeloma Forum (PDF 60 KB)

Welsh Assembly Government

Welsh Assembly Government (PDF 75 KB)

Ortho Biotech

Ortho Biotech (PDF 670 KB)

Expert statements

Jackson

Jackson (PDF 45 KB)

Jago

Jago (PDF 17 KB)

Morgan

Evidence considered

Pre Meeting Briefing

Pre Meeting Briefing (PDF 473 KB)

Multiple myeloma - bortezomib: evidence review group report

Multiple myeloma - bortezomib: evidence review group report (PDF 1.86 MB)

Manufacturer/sponsor submission (Ortho Biotech)

Manufacturer/sponsor submission (Ortho Biotech) (PDF 964 KB)

Expert comments on the ACD

Jackson

Jackson (PDF 449 KB)

Jago

Jago (PDF 63 KB)

Low

Low (PDF 363 KB)

Morgan