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Guidance on the use of temozolomide for the treatment of recurrent malignant glioma (brain cancer)

  • Technology appraisal guidance
  • Reference number: TA23
  • Published:  26 April 2001
  • Last updated:  03 March 2016
  • Guidance
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  • Information for the public
  • Evidence
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  • Overview
  • 1 Recommendations
  • 2 Clinical need and practice
  • 3 The technology
  • 4 Evidence
  • 5 Implications for the NHS
  • 6 Further research
  • 7 Implementation
  • 8 Appraisal Committee members
  • 9 Sources of evidence
  • 10 Karnofsky performance score
  • 11 The new WHO classification of tumours affecting the central nervous system
  • Update information

Update information

March 2016: The wording of recommendation 1.1 has been updated in line with NICE's wording conventions.

Recommendations 1.2 and 1.3 for temozolomide for the first‑line chemotherapy treatment of malignant glioma when primary therapy (surgery and/or radiotherapy) has failed, have been updated recommendation 1.1 in NICE's technology appraisal guidance on carmustine implants and temozolomide for the treatment of newly diagnosed high-grade glioma.

ISBN: 978-1-4731-1789-1


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